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Contributor Information

  • Name Alfred Schinkel
  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Mrp2 Knock Out Mouse
  • Alternate names: Multidrug resistance-associated protein 2, MRP2, cMOAT, ABCC2
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Model: Conditional KO
  • Model description: This strain encodes a disruption of the Abcc2 gene which codes for multidrug resistance protein 2.
  • Conditional: Yes
  • Application: Useful for the examination of compound uptake and elimination mechanisms as well as studies on drug resistance in tumors.
  • Genetic background and cross history: The model was created by targeting the Abcc2 gene in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations.
  • Phenotype: Albino
  • Zygosity: The colony is maintained by mating homozygotes. Wild type for Nnt mutation; carries Pde6brd1 mutation
  • Description: Multidrug resistance associated protein 2 is a member of the super family of ATP-binding cassette (ABC) transporters. These proteins are involved in transport of various molecules across extra and intracellular membranes.
  • Research area: Cancer; Cell signaling and signal transduction; Drug development
  • Production details: The model was created by targeting the Abcc2 gene in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations.
  • Additional notes: This strain encodes a disruption of the Abcc2 gene which codes for multidrug resistance protein 2. Useful for the examination of compound uptake and elimination mechanisms as well as studies on drug resistance in tumors. The Mrp2 mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute.

  • For Research Use Only

Target Details

  • Target: Abcc2 gene

Application Details

  • Application: Useful for the examination of compound uptake and elimination mechanisms as well as studies on drug resistance in tumors.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  van Waterschoot et al. 2010. Br J Pharmacol. 160(5):1224-33. PMID: 20590614.
  • •  Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.
  • •  Vlaming et al. 2006. J Pharmacol Exp Ther. 318(1):319-27. PMID: 16611851.
  • •  Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.