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Contributor Information

  • Name Ben Emery
  • Institute Oregon Health & Science University

Tool Details

  • Tool name: Sox10iCre/+; Myrffl/fl mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: inducible demyelination without remyelination
  • Genetic background and cross history: MyrfFl/Fl mouse line crossed with a Sox10-CreERT transgenic line expressing tomoxifen inducible Cre recombinase in the oligodendrocyte lineage.
  • Phenotype: Demyelination of CNS
  • Strain: C57BL/6
  • Description: Deymelination restricted to CNS & lack of remyelination.
  • Research area: Neurobiology
  • Breeding information: Sox10iCre/+;MyrfFl/Fl mouse line can be bred with Sox10+/+;MyrfFl/Fl mice where 50% offspring will be Sox10iCre/+.

  • For Research Use Only

Target Details

  • Target: Myrf (myelin regulatory factor)

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  30996143 19596243
  • •  McKenzie et al. 2014. Science. 346(6207):318-22. PMID: 25324381.
  • •  Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.