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Contributor Information

  • Name Eyal Gottlieb
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: SDHB Floxed Mouse
  • Alternate names: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Cancer
  • Model: Transgenic
  • Conditional description: Exon 3 of the succinate dehydrogenase can be deleted upon Cre recombinase expression as this exon is flanked with lox P sequences
  • Genetic background and cross history: Backcrossed 10 times into C57/BL6
  • Zygosity: Homozygous
  • Strain: C57BL/6
  • Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
  • Research area: Cancer; Drug development; Genetics; Metabolism

  • For Research Use Only

Target Details

  • Target: Succinate dehydrogenase

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
  • •  Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.