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Contributor Information

  • Name Colin Henderson ; Roland Wolf
  • Institute University of Dundee

Tool Details

  • Tool name: HBRN Mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Conditional: No
  • Genetic background and cross history: HBRN (Cytb5lox/lox::PORlox/lox CreALB) and wild-type (WT; PORlox/lox::Cyb5lox/lox) were generated by crossing HRN (PORlox/lox + CreALB ) and floxed cytochrome b5 mice (Cytb5lox/lox), and thereafter maintained by crossing of homozygous pairs within each line.
  • Zygosity: HBRN (Cytb5lox/lox::PORlox/lox ą CreALB)
  • Description: Improved model of abrogation of hepatic P450 function. The dual deletion of both Cyb5 and POR almost completely abrogates all hepatic cytochrome P450 activities; the new HBRN model thus provides a more authentic hepatic-P450 null phenotype
  • Research area: Cell signaling and signal transduction; Genetics; Metabolism
  • Production details: HBRN (Cytb5lox/lox::PORlox/lox Âą CreALB) and wild-type (WT; PORlox/lox::Cyb5lox/lox) were generated by crossing HRN (PORlox/lox + CreALB ) and floxed cytochrome b5 mice (Cytb5lox/lox), and thereafter maintained by crossing of homozygous pairs within each line.

  • For Research Use Only

Target Details

  • Target: P450, Cyb5

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.
  • •  Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.
  • •  Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.
  • •  Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.