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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-CD227 (MUC1) [139H2]
  • Alternate names: Mucin 1, Cell Surface Associated
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Breast cancer; Gynaecologic cancer; Digestive / Gastrointestinal cancer;
  • Molecular weight of the target: 120 kDa
  • Application: EM (EM) ; ELISA ; FACS ; IHC ; IF ; IP ; WB
  • Description: MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers
  • Immunogen: Milkfat globule membranes
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: CD227
  • Target molecular weight: 120 kDa
  • Target background: MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers

Application Details

  • Application: EM (EM) ; ELISA ; FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hilkens et al. 1984. Int J Cancer. 34(2):197-206. PMID: 6206003.