ANTIBODIES
Contributor Information
- Name Peter Beverley
- Institute University College London (UCL)
Tool Details
- Tool name: Anti-Leu1 [UCH-T2]
- Alternate names: CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1
- Clone: UCH-T2
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Cancer type: Blood cancer
- Application: IHC ; IF ; WB
- Strain: Balb/c
- Description: UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.
- Immunogen: Thymocytes followed by Sezary T cells.
- Isotype: IgG1 kappa
- Research area: Immunology; Stem cell biology
- For Research Use Only
Target Details
- Target: Leu1 (CD5)
- Target background: Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis.
Application Details
- Application: IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
References
- • Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8.
- • Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671.
- • A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
- • Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
- • Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
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