ANTIBODIES

Contributor Information
- Name Fiona Benson
- Institute Lancaster University
Tool Details
- Tool name: Anti-TDP43 [DB9]
- Clone: DB9
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; WB
- Description: Monoclonal antibody used in study of TDP-43 associated diseases. Background and Research Application TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
- Immunogen: A his-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.
- Immunogen UniProt ID: Q13148
- Isotype: IgG1 kappa
- Research area: Genetics; Neurobiology; Microbiology
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: TDP43
- Target background: Monoclonal antibody used in study of TDP-43 associated diseases. Background and Research Application TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
Application Details
- Application: ELISA ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC