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Contributor Information

  • Name Fiona Benson
  • Institute Lancaster University

Tool Details

  • Tool name: Anti-TDP43 [DB9]
  • Clone: DB9
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; WB
  • Description: Monoclonal antibody used in study of TDP-43 associated diseases. Background and Research Application TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
  • Immunogen: A his-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.
  • Immunogen UniProt ID: Q13148
  • Isotype: IgG1 kappa
  • Research area: Genetics; Neurobiology; Microbiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: TDP43
  • Target background: Monoclonal antibody used in study of TDP-43 associated diseases. Background and Research Application TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation