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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD11C [118/A5] mAb
  • Clone: 118/A5
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC
  • Description: The integrin alpha X chain protein (CD11c) belongs to the ?Ÿ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?Ÿ subunit. CD11c (the a subunit) combines with CD18 (the ?Ÿ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.
  • Immunogen: Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK
  • Isotype: IgG2b
  • Research area: Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX
  • Target background: The integrin alpha X chain protein (CD11c) belongs to the ?Ÿ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?Ÿ subunit. CD11c (the a subunit) combines with CD18 (the ?Ÿ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.

Application Details

  • Application: IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.
  • •  Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.
  • •  Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.
  • •  Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.
  • •  Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.
  • •  The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
  • •  Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.
  • •  Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.