Product Image

Contributor Information

  • Institute Hudson Institute Of Medical Research

Tool Details

  • Tool name: HtrA3 (Clone 6G6)
  • Alternate names: HtrA3, High-temperature requirement factor A3, Pregnancy-related serine protease
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 48 kDa (46.9 kDa plus 1 kDa for the His tag)
  • Application: IHC ; WB
  • Strain: Balb/c
  • Description: Potential marker for preeclampsia. Detection of endogenous HtrA3 proteins in human serum HtrA3 are oligomeric serine proteases involved in protein quality control , regulate signal transduction in cell growth, apoptosis, inflammation in cancer, arthritis, neurodegenerative and neuromuscuclar disorders, age-related macular degeneration, pregnancy-specific disease preecampsia
  • Immunogen: HtrA3-L-S305A protein
  • Immunogen UniProt ID: P83110, HTRA3_HUMAN
  • Research area: Tissue-specific biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Long isoform Human HtrA3 (high temperature requirement factor A)
  • Target molecular weight: 48 kDa (46.9 kDa plus 1 kDa for the His tag)
  • Target background: Potential marker for preeclampsia. Detection of endogenous HtrA3 proteins in human serum HtrA3 are oligomeric serine proteases involved in protein quality control , regulate signal transduction in cell growth, apoptosis, inflammation in cancer, arthritis, neurodegenerative and neuromuscuclar disorders, age-related macular degeneration, pregnancy-specific disease preecampsia

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-Xylan/arabinoxylan [LM11]

#157952
Product Image

Anti-O-linked N-acetylglucosamine (O-GlcNAc) [3C1.E8]

#153897
Product Image

Anti-Integrin alpha 6 [MP4F10]

#151134

References

  • •  Wang et al. 2018. SLAS Discov. 23(10):1092-1099. PMID: 27932697.
  • •  HtrA3 Isoform-Specific ELISAs for Early Detection of Preeclampsia.
  • •  Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.
  • •  Singh et al. 2014. PLoS One. 9(9):e108235. PMID: 25248123.
  • •  HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.
  • •  Dynon et al. 2012. PLoS One. 7(9):e45956. PMID: 23049902.