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Contributor Information

  • Name Maria E Teves Ph.D., Jerome F Strauss III M.D Ph.D., and John Varga M.D.
  • Institute Virginia Commonwealth University
  • Primary citation Sapao et al. J Invest Dermatol. 143(2):284-293 PMID: 36116512

Tool Details

  • Tool name: Fibroblast specific Spag17 knockout mouse
  • Tool type: Mouse
  • Disease: Fibrotic Disease and systemic sclerosis
  • Model: Knock-out
  • CRISPR: No
  • Phenotype: Multi-organ fibrosis
  • Description: This is a fibroblast specific, Tamoxifen inducible knockout mouse model for the deletion of the Spag17 gene.
    Reserachers identified the Spag17 gene as one differentially regulated in fibrotic diseases and created a mouse model was created with inducible fibroblast specific Spag17 knockout. Knockout Spag17 mice show significant fibrosis in skin, heart, lungs, kidneys, and skeletal muscle between 4-6 months of age. These mice have greater collagen deposition, enhanced fibroblast to myofibroblast transition, and changes in morphogen activity. They also mimic the pathophysiology of systemic sclerosis great for studying multi-organ fibrosis.
  • Research area: Systemic sclerosis and fibrosis

  • For Research Use Only

Target Details

Application Details

Handling

Documentation

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References

  • •  Sapao et al. J Invest Dermatol. 143(2):284-293 PMID: 36116512