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Contributor Information

  • Name Ben Emery
  • Institute Oregon Health & Science University

Tool Details

  • Tool name: iCKO-Myrf mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Tamoxifen inducible knockout of Myrf in mature oligodendrocytes
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: inducible conditional myelin regulatory factor knockout mouse
  • Genetic background and cross history: MyrfFl/Fl male + PLP-Cre/MyrfFl/Fl female or PLP-Cre/MyrfFl/Fl male + MyrfFl/Fl female. Provides iCKO-Myrf pups at 50%
  • Phenotype: iCKO-Myrf
  • Strain: C57BL/6
  • Description: inducible knockout of Myrf in oligodendrocytes, critical for myelin formation in CNS.
  • Research area: Neurobiology
  • Breeding information: MyrfFl/Fl male + PLP-Cre/MyrfFl/Fl female or PLP-Cre/MyrfFl/Fl male + MyrfFl/Fl female. Provides iCKO-Myrf pups at 50%

  • For Research Use Only

Target Details

  • Target: Myrf (myelin regulatory factor)

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.
  • •  Emery et al. 2009. Cell. 138(1):172-85. PMID: 19596243.
  • •  Doerflinger et al. 2003. Genesis. 35(1):63-72. PMID: 12481300.