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Contributor Information

  • Name Franz Radner
  • Institute University of Graz

Tool Details

  • Tool name: G0S2-flox mouse
  • Alternate names: G0/G1 swithc gene 2
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Model: Knock-Out
  • Conditional: Yes
  • Conditional description: Flox flanked gene ready for deletion
  • Genetic background and cross history: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
  • Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
  • Zygosity: Homozygous
  • Strain: C57BL/6J
  • Description: seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
  • Research area: Cancer; Metabolism; Cell biology; Apoptosis and autophagy
  • Production details: The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request.
  • Breeding information: Good breeder. Homozygous mice may be bred together to maintain a live colony.

  • For Research Use Only

Target Details

  • Target: G0/G1 switch gene 2

Application Details

Handling

Documentation

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References

  • •  Heier et al. 2015. J Biol Chem. 290(43):26141-50. PMID: 26350455.