EXPERIMENTAL MODELS
Contributor Information
- Name Gregorio Gil
- Institute Virginia Commonwealth University
Tool Details
- Tool name: StarD5 Knock-out Mouse
- Tool type: Experimental models
- Tool sub-type: Mouse
- Disease: Heart disease; Heart attack and stroke
- Model: Knock-Out
- Model description:
- Description: StarD5 protein is knocked out in the entire mouse to study the effects of disrupting pathways associated with cholesterol and resultant pathological conditions.
- Research area: Tissue-specific biology; Drug development
- Production details: The StarD5 knock-out mouse was produced by designing a guide RNA to create a double-strand cleavage upstream of the ATG start site. Pups were obtained, screened and sequenced. Heterozygous male and female mice were crossed to generate homozygous StarD5 knock-out mice.
- For Research Use Only
Target Details
- Target: StarD5
Application Details
Handling
Documentation
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