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Contributor Information

  • Name Jerzy Kotlinowski ; Natalia Pydyn ; Edyta Kus ; Stefan Chlopicki ; Jolanta Jura
  • Institute Jagiellonian University

Tool Details

  • Tool name: Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1) knockout mouse
  • Alternate names: Regnase1, Zc3h12a
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Human primary biliary cholangitis
  • Model: Knock-Out
  • Phenotype: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522: This mouse model was developed to verify whether Mcpip1 expression protects against development of PBC. Deletion of hepatic Mcpip1 in Mcpip1AlbKO mice leads to development of PBC that recapitulates phenotype of human patients. These animals, show early prenatal origin and age-dependent progression of the disease.
  • Description: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522: Primary biliary cholangitis (PBC) is an autoimmune disease characterized by progressive destruction of the intrahepatic bile ducts. The immunopathology of PBC involves excessive inflammation; therefore, negative regulators of inflammatory response, such as Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1, alias Regnase1) may play important roles in the development of PBC.
  • Research area: Immunology
  • Additional notes: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522: This mouse model was developed to verify whether Mcpip1 expression protects against development of PBC. Deletion of hepatic Mcpip1 in Mcpip1AlbKO mice leads to development of PBC that recapitulates phenotype of human patients. These animals, show early prenatal origin and age-dependent progression of the disease.

  • For Research Use Only

Target Details

  • Target: Monocyte Chemoattractant Protein-1-Induced Protein-1

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Deletion of Mcpip1 in Mcpip1AlbKO mice recapitulates the phenotype of human primary biliary cholangitis