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Contributor Information

  • Name Bart Vanhaesebroeck
  • Institute Ludwig Institute for Cancer Research ; The University of Edinburgh

Tool Details

  • Tool name: p110beta PI3K-DEL21/22 (B6)
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Model: Knock-Out
  • Cell signalling pathway: PI3K/AKT signalling
  • Genetic background and cross history: Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
  • Phenotype: Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.
  • Research area: Cancer
  • Production details: Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
  • Additional notes: Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.

  • For Research Use Only

Target Details

  • Target: PIK3CB

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
  • •  Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.