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Contributor Information

  • Name Fred W. Perrino
  • Institute Wake Forest University

Tool Details

  • Tool name: Trex1 R114H Mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Lupus
  • Model: Mutant
  • Model description:
  • Conditional: No
  • Genetic background and cross history: Mutant mice were generated on a 129S6/SvEvTac background using an allelic replacement strategy.
  • Description: TREX1 encodes a DNA exonuclease and mutations in this gene result in multiple autoimmune disorders, including lupus. This particular mouse model mimics Aicardi-Goutières Syndrome, a form of Lupus.
  • Research area: Immunology; Neurobiology; Cell signaling and signal transduction; Drug development

  • For Research Use Only

Target Details

  • Target: TREX1

Application Details

Handling

Documentation

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References

  • •  Grieves et al. 2015. Proc Natl Acad Sci U S A. 112(16):5117-22. PMID: 25848017.
  • •  Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.