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Contributor Information

  • Name Tomas Lindahl
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Trex1 -/- Mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Antiviral-like autoimmunity; Autoinflammatory disease; Aicardi-Goutieres syndrome
  • Model: Knock-Out
  • Conditional: No
  • Genetic background and cross history: Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.
  • Phenotype: Autoimmunity manifested as inflammatory myocarditis / reduced lifespan
  • Zygosity: Homozygous
  • Description: Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse
  • Research area: Drug development; Genetics; Immunology
  • Production details: Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.

  • For Research Use Only

Target Details

  • Target: TREX1

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.
  • •  Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
  • •  Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.
  • •  Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.