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Contributor Information

  • Name Mikhail Plentnikov
  • Institute Johns Hopkins University

Tool Details

  • Tool name: Mutant DISC1 cell line
  • Tool type: Cell Lines
  • Parental cell line: PC12
  • Disease: Schizophrenia
  • Description: To evaluate the effects of a predicted protein, mutant disrupted-in-schizophrenia 1 (DISC1), stable PC12 cell clones with inducible expression of mutant or full-length human DISC1 (hDISC1) have been generated. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable expression of full-length and truncated hDISC1, allowing for a regulated expression of hDISC1 in homogenous populations of cells. Inducible expression of DISC1 in PC12 cells is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses.
  • Research area: Neurobiology; Drug development

  • For Research Use Only

Target Details

  • Target: disrupted-in-schizophrenia 1 (DISC1)

Application Details

Handling

  • Format: Frozen
  • Shipping conditions: Dry ice

Documentation

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References