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Contributor Information

  • Name Shaun Cowley
  • Institute University of Leicester

Tool Details

  • Tool name: Lysine Specific Demethylase 1 (LSD1) knockout mouse
  • Alternate names: LSD1, KDM1A, AOF2, KDM1, KIAA61, LSD1
  • Tool type: Cell Lines
  • Disease: Cleft palate, psychomotor retardation, and distinctive facial features (CPRF)
  • Growth properties: gene-trap
  • Model: Knock-Out
  • Conditional: No
  • Description: Lysine-specific demethylase 1 (LSD1) acts as a coactivator or a corepressor of transcription, depending on the context, of histone H3 through demethylation of both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me). It demethylates mono- and dimethylated histone H3 as part of a larger complex. It essential for embryonic development in the mouse beyond embryonic day 6.5. Using this mouse model it was found that LSD1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.
  • Research area: Developmental biology
  • Production details: Embryos at the desired developmental stage were produced from timed Lsd1+/Î?‹Â›-geo ?„‚?‚— Lsd1+/Î?‹Â›-geo matings

  • For Research Use Only

Target Details

  • Target: Lysine-Specific Demethylase 1

Application Details

Handling

  • Format: Frozen
  • Shipping conditions: Dry ice

Documentation

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