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Contributor Information

  • Name Julian Downward, Jesse Boumelha, Sophie de Carne
  • Institute The Francis-Crick Institute
  • Primary citation Boumelha et al. 2022. Cancer Research. 82(19):3435-3448. PMID: 35930804.

Tool Details

  • Tool name: KPAR1.3 Cell Line
  • Alternate names:  
  • Tool type: Cell Lines
  • Organism: Mouse
  • Tissue: Lung
  • Cancer type: Lung cancer
  • Model: Mutant
  • Model description: Single cell clone from a cell line isolated from KrasLSL-G12D/+; Trp53fl/fl; Rosa26A3Bi;Rag1–/– mouse (KPAR) lung tumours
  • CRISPR: No
  • Description: Mouse models of mutant KRAS-driven lung cancer with an elevated tumour mutational burden by expressing the human DNA cytosine deaminase, APOBEC3B, to mimic the mutational signature seen in human lung cancer. The ability of KRAS/KRASG12 inhibitors to cause regression of KRASG12C expressing tumours was markedly potentiated by the adaptive immune system.
  • Research area: Cancer
  • Production details: Single cell clone from a cell line isolated from KrasLSL-G12D/+; Trp53fl/fl; Rosa26A3Bi;Rag1–/– mouse (KPAR) lung tumours

  • For Research Use Only

Target Details

Application Details

Handling

  • Growth medium: DMEM media supported with 10% FBS, glutamine and penicillin/streptomycin
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Cultured in antibiotics?: Penicillin, Streptomycin
  • Biosafety level: CL-1

Documentation

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References

  • •  Boumelha et al. 2022. Cancer Research. 82(19):3435-3448. PMID: 35930804.