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Contributor Information

  • Name Carl G. Figdor
  • Institute Radboud University Medical Center (UMC)

Tool Details

  • Tool name: Anti-ALCAM AZN-L50 (IgG2A) [AZNL50]
  • Alternate names: CD166 antigen, MEMD
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IP ; WB ; IP ; WB
  • Strain: Balb/c
  • Description: ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation. It also engages in homotypic cell-cell contacts. These ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression.
  • Immunogen: K562-ALCAM
  • Immunogen UniProt ID: Q13740
  • Isotype: IgG2a
  • Research area: Cell biology; Cancer; Immunology

  • For Research Use Only

Target Details

  • Target: Activated leukocyte cell adhesion molecule
  • Target background: ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation. It also engages in homotypic cell-cell contacts. These ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression.

Application Details

  • Application: FACS ; IP ; WB ; IP ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Te Riet et al. 2007. J Cell Sci. 120(Pt 22):3965-76. PMID: 17971418.