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Contributor Information

  • Name Helen Hurst
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-AP2g [AP2g 6E4/4]
  • Clone: AP2g 6E4/4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Molecular weight of the target: 50 kDa
  • Application: IHC ; IP ; WB
  • Strain: Balb/c
  • Description: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?Ÿ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
  • Immunogen: Bacterially produced AP-2a/AP-2g fusion protein (c-terminal half of AP-2 gamma)
  • Isotype: IgG1
  • Research area: Cancer; Tissue-specific biology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Activating Protein 2 (AP-2) gamma
  • Target molecular weight: 50 kDa
  • Target background: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.

Application Details

  • Application: IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Gee et al. 2009. J Pathol. 217(1):32-41. PMID: 18825690.
  • •  Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival.
  • •  Eloranta et al. 2002. J Biol Chem. 277(34):30798-804. PMID: 12072434.
  • •  Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.