ANTIBODIES

Contributor Information
- Name Abdo Alnabulsi
- Institute Vertebrate Antibodies Limited
Tool Details
- Tool name: Anti-IGF
- Tool type: Antibodies
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Avian
- Host: Rabbit
- Molecular weight of the target: 17
- Application: ELISA
- Description: Insulin-like growth factor 1 (IGF-1) is produced by the liver and skeletal muscle as well as many other tissues in response to growth hormone (GH) stimulation. IGF-1 mediates many of the actions of GH, stimulating the growth of bones and other tissues and promoting the production of lean muscle mass. IGF-1 is a useful indicator of average GH levels. The IGF-1 test is therefore often used to help evaluate for GH deficiency or GH excess. IGF-1 deficiencies are seen early in life and are usually the result of GH deficiency. They can inhibit bone growth and overall development and can result in a child with a shorter than normal stature. In adults, decreased production can lead to low bone density, less muscle mass, and altered lipid levels. Insulin-like growth factor 1 (IGF-1) is an evolutionary conserved peptide, which has been shown to be essential in the regulation of body size, the pattern of reproductive investment and life span across a broad taxonomic range of model species in laboratory and domesticated conditions. However, studies addressing corresponding evolutionary hypotheses on a broader scale and in free-living vertebrates are very rare. This is a very useful research tool to monitor muscle development and metabolism in birds.
- Immunogen: Ovalbumin-conjugated synthetic peptide. Peptide immunogen is conserved in all bird species
- Research area: Cell biology; Immunology
- For Research Use Only
Target Details
- Target: Insulin-like growth factor 1 (IGF)
- Target molecular weight: 17
- Target background: Insulin-like growth factor 1 (IGF-1) is produced by the liver and skeletal muscle as well as many other tissues in response to growth hormone (GH) stimulation. IGF-1 mediates many of the actions of GH, stimulating the growth of bones and other tissues and promoting the production of lean muscle mass. IGF-1 is a useful indicator of average GH levels. The IGF-1 test is therefore often used to help evaluate for GH deficiency or GH excess. IGF-1 deficiencies are seen early in life and are usually the result of GH deficiency. They can inhibit bone growth and overall development and can result in a child with a shorter than normal stature. In adults, decreased production can lead to low bone density, less muscle mass, and altered lipid levels. Insulin-like growth factor 1 (IGF-1) is an evolutionary conserved peptide, which has been shown to be essential in the regulation of body size, the pattern of reproductive investment and life span across a broad taxonomic range of model species in laboratory and domesticated conditions. However, studies addressing corresponding evolutionary hypotheses on a broader scale and in free-living vertebrates are very rare. This is a very useful research tool to monitor muscle development and metabolism in birds.
Application Details
- Application: ELISA
Handling
- Format: Liquid
- Storage buffer: Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal
- Storage conditions:
- Shipping conditions: Shipping at 4ðC