ANTIBODIES
Contributor Information
- Name Jonathon Pines
- Institute University of Cambridge
Tool Details
- Tool name: Anti-APC11 [CRQ1.1]
- Clone: CRQ1.1
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: WB
- Description: The anti-APC11 antibody, clone CRQ1.1 has been raised in mouse against the C-terminal portion of APC11 and it reacts with human. APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo.
- Immunogen: C-terminal peptide - CRQEWKFKE
- Isotype: IgG2a
- Research area: Cell biology; Biochemistry
- For Research Use Only
Target Details
- Target: APC11, Cyclosome subunit 11
- Target background: The anti-APC11 antibody, clone CRQ1.1 has been raised in mouse against the C-terminal portion of APC11 and it reacts with human. APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo.
Application Details
- Application: WB
Handling
- Format: Liquid
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -20Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.
- • Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.
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