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Contributor Information

  • Institute Johns Hopkins University

Tool Details

  • Tool name: Anti-Pirt
  • Tool type: Antibodies
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Application: IHC
  • Description: Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of pain. Its channel activity can be modulated by several mechanisms. Phosphoinositide interacting regulator of TRP (Pirt), a membrane protein, expressed specifically in the peripheral nervous system (PNS), predominantly in nociceptive (pain) neurons has been described by several experiments indicating that Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. To further study this signaling pathway, a rabbit polyclonal anti-Pirt antibody that recognizes the Pirt protein has been developed.
  • Research area: Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: phosphoinositide interacting regulator of TRP (Pirt)
  • Target background: Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of pain. Its channel activity can be modulated by several mechanisms. Phosphoinositide interacting regulator of TRP (Pirt), a membrane protein, expressed specifically in the peripheral nervous system (PNS), predominantly in nociceptive (pain) neurons has been described by several experiments indicating that Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. To further study this signaling pathway, a rabbit polyclonal anti-Pirt antibody that recognizes the Pirt protein has been developed.

Application Details

  • Application: IHC

Handling

  • Format: Liquid
  • Storage buffer:
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Kim et al. 2008. Cell. 133(3):475-85. PMID: 18455988.