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Contributor Information

  • Name John Kemshead
  • Institute Institute of Child Health

Tool Details

  • Tool name: Anti-Integrin a2b [M148]
  • Alternate names: Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
  • Clone: M148
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 110-130 kDa
  • Application: FACS ; IHC ; IF ; IP ; Fn
  • Strain: Balb/c
  • Description: M148 prevents aggregation of platelets. Used for imaging and therapy of thrombi. M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumours. No binding is observed to marrow constituents other than platelets and megakaryocytes.
  • Immunogen: Homogenized human medulloblastoma tissue.
  • Isotype: IgG1
  • Research area: Cell signaling and signal transduction; Cell biology; Extracellular Matrix
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Integrin alpha 2b (CD41)
  • Target molecular weight: 110-130 kDa
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin ?3 (CD61) associate to form the heterodimer integrin a2b?3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646.
  • •  Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction.
  • •  Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896.
  • •  The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.
  • •  Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261.
  • •  Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.
  • •  Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.
  • •  A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.