Product Image

Contributor Information

  • Institute Absolute Antibody; Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-DMC1 [2H12/4] rAb
  • Alternate names: Disrupted meiotic cDNA 1 homolog, Disrupted meiotic cDNA 1, yeast homolog of, dJ199H16.1, DMC 1, DMC1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast), DMC1 homologue
  • Clone: 2H12/4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human ; Mouse
  • Host: Mouse
  • Description: DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.
  • Immunogen: human DMC1 protein (expressed as 6xHis fusion in E. coli and band cut out of gel of insoluble pelet)
  • Isotype: IgG2a
  • Research area: Genetics

  • For Research Use Only

Target Details

  • Target: DMC1
  • Target background: DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.

Application Details

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-OxPL [mAB-509]

#160858
Product Image

Anti-p53 [Pab 1802]

#151145
Product Image

Anti-Integrin a4 [BU49]

#151439

References

  • •  Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.
  • •  Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.
  • •  Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.
  • •  Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
  • •  The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
  • •  The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.