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Anti-p53 [Pab 1802]

Cat. #151145

Name Lawrence Banks
Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Primary citation Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.

Tool name: Anti-p53 [Pab 1802]
Alternate names: Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome; P53 Tumor Suppressor; Tumor Suppressor P53; TRP53; BCC7; LFS1
Clone: Pab 1802
Tool type: Antibodies
Tool sub-type: Primary antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Human ; Mouse
Host: Mouse
Cancer type: Broadly Applicable
Molecular weight of the target: 53 kDa
Application: ELISA ; IHC ; IP ; WB
Description: Pab 1802 is a monoclonal antibody for p53. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53. Pab 1802 has been used to show the expression of human p53 cDNA in cos-I cells.
Immunogen: P53-beta galactosidase fusion protein
Isotype: IgG1
Research area: Apoptosis and autophagy; Cancer; Cell biology; Genetics
Myeloma used: P3/NS1/1-Ag4.1

Target: p53
Target molecular weight: 53 kDa
Target background: p53 is a crucial tumour suppressor involved in over 50% of cancers. It acts as a stress-responsive transcription factor and plays a vital role in regulating cell cycle arrest, promoting apoptosis, maintaining genomic stability, controlling the cell cycle, and inhibiting angiogenesis. Known as the "guardian of the genome," p53 prevents gene mutations.

Mutations in the p53 gene are common in human cancers, resulting in dysfunctional proteins unable to bind to DNA. This loss of function compromises p53's tumour suppressor activity. While p53 is typically found in low levels in healthy cells due to its short lifespan, disease states lead to increased expression driven by somatic mutations. This heightened expression is believed to contribute to cellular transformation and malignancy.

Twelve isoforms of p53 have been described: p53Îą, p53Î˛, p53Îł, Î40p53Îą, Î40p53Î˛, Î40p53Îł, Î133p53Îą, Î133p53Î˛, Î133p53Îł, Î160p53Îą, Î160p53Î˛, and Î160p53Îł. Depending on the location of the epitope, antibodies may detect different isoforms of p53. Mutations to p53 can cause conformational changes that expose different epitopes. Pab 1802 is a monoclonal antibody for p53, it has been used to show the expression of human p53 cDNA in cos-I cells. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53.

£ 300
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