ANTIBODIES

Contributor Information
- Institute Netherlands Cancer Institute
Tool Details
- Tool name: Anti-CD8 [SPVT8]
- Alternate names: Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 32 kDa
- Application: FACS ; IP
- Strain: Balb/c
- Description: CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides
- Immunogen: Human cytotoxic T-lymphocytes
- Isotype: IgG1
- Research area: Cell biology; Immunology
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: CD8
- Target molecular weight: 32 kDa
- Target background: CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides
Application Details
- Application: FACS ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
Related Tools
References
- • de Vries et al. 1984. J Immunol. 132(1):510-9. PMID: 6197458.
- • Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.