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Contributor Information

  • Institute Absolute Antibody; University of Oxford

Tool Details

  • Tool name: Anti-CD79a [JCB117] rAb
  • Alternate names: CD79a Molecule; Membrane-Bound Immunoglobulin-Associated Protein; Surface IgM-Associated Protein; MB-1 Membrane Glycoprotein; Ig-Alpha; IGA; CD79a Antigen; MB1
  • Clone: JCB117
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Blood cancer
  • Description: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.
  • Immunogen: Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction; Immunology; Stem cell biology

  • For Research Use Only

Target Details

  • Target: CD79a
  • Target background: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.

Application Details

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Arana et al. 2016. J Clin Pathol. :. PMID: 27484914.
  • •  Boudova et al. 2005. Am J Dermatopathol. 27(5):375-86. PMID: 16148405.
  • •  Boudova et al. 2006. J Cutan Pathol. 33(8):584-9. PMID: 16919035.
  • •  CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.
  • •  Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma.
  • •  Cutaneous lymphoid hyperplasia and other lymphoid infiltrates of the breast nipple: a retrospective clinicopathologic study of fifty-six patients.
  • •  Delli et al. 2016. Ann Rheum Dis. :. PMID: 26757748.
  • •  HBME-1 is expressed by erythroid precursors in early maturation stage and can be a valuable tool for evaluation of dyserythropoiesis in bone marrow core biopsy specimens.
  • •  Higashi et al. 2015. Leuk Lymphoma. :1-6. PMID: 25860238.
  • •  Korkolopoulou et al. 1994. Histopathology. 24(6):511-5. PMID: 7520411.
  • •  Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
  • •  Mason et al. 1995. Blood. 86(4):1453-9. PMID: 7632952.
  • •  Pilozzi et al. 1998. J Pathol. 186(2):140-3. PMID: 9924428.
  • •  Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman.
  • •  Radaev et al. 2010. Structure. 18(8):934-43. PMID: 20696394.
  • •  Structural and Fn studies of Igalphabeta and its assembly with the B cell antigen receptor.
  • •  The expression of the B-cell marker mb-1 (CD79a) in Hodgkin's disease.
  • •  Towards personalised treatment in primary Sjgren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment.