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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-Melanoma Associated Antigen 100 (Gp100) [Beteb]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 70 kDa
  • Application: IHC
  • Strain: Balb/c
  • Description: Gp100 plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumour cells from antibody mediated immunity.
  • Immunogen: Purified membranes of a human melanoma lymph node metastasis
  • Isotype: IgG2b
  • Research area: Cancer; Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Melanoma Associated Antigen 100
  • Target molecular weight: 70 kDa
  • Target background: Gp100 plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumour cells from antibody mediated immunity.

Application Details

  • Application: IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Vennegoor et al. 1988. Am J Pathol. 130(1):179-92. PMID: 3276209.