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Contributor Information

  • Name Helen Turley ; Deborah Goberdhan
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-PAT4 [PAT-4/9/H10]
  • Clone: PAT-4/9/H10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: ~60 kDa
  • Application: IHC ; WB
  • Description: The Anti-PAT4 [PAT-4/9/H10] antibody is a highly specific mouse monoclonal antibody against PAT4. Members of the proton-assisted amino-acid transporter (PAT) or solute-linked carrier 36 (SLC36) family have been identified as positive regulators of growth and mTORC1 signalling in flies.These effects were shown to be conserved by characterisation of the two ubiquitously transcribed human PATs, PAT1 (SLC36A1) and PAT4 (SLC36A4). PAT4 is upregulated in aggressive forms of colorectal cancer and a possible biomarker.
  • Immunogen: Antigenic amino acid sequence within the N-terminus of PAT4 (REELDMDVMRPLINE-C).
  • Isotype: IgG2a kappa
  • Research area: Cell signaling and signal transduction; Metabolism
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: PAT4 (SLC36A4)
  • Target molecular weight: ~60 kDa
  • Target background: The Anti-PAT4 [PAT-4/9/H10] antibody is a highly specific mouse monoclonal antibody against PAT4. Members of the proton-assisted amino-acid transporter (PAT) or solute-linked carrier 36 (SLC36) family have been identified as positive regulators of growth and mTORC1 signalling in flies.These effects were shown to be conserved by characterisation of the two ubiquitously transcribed human PATs, PAT1 (SLC36A1) and PAT4 (SLC36A4). PAT4 is upregulated in aggressive forms of colorectal cancer and a possible biomarker.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Fan et al. 2015. Oncogene. :. PMID: 26434594.
  • •  PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer.