ANTIBODIES
Contributor Information
- Institute Netherlands Cancer Institute
Tool Details
- Tool name: Anti-TCR gamma delta [11F2] monoclonal antibody
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IP
- Strain: Balb/c
- Description: This monoclonal antibody recognises the gamma delta T cell receptor (gamma delta TCR). This antibody can be used to detect populations of gamma delta T cells. This antibody reacts with human gamma delta TCR in native as well as denatured states.
- Immunogen: Purified native TCRg/d
- Isotype: IgG1
- Research area: Cell signaling and signal transduction; Immunology
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: TCR yd
- Target background: The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognising fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The TCR is composed of two different protein chains. In humans, in 95% of T cells the TCR consists of an alpha chain and a beta chain, whereas in 5% of T cells the TCR consists of gamma and delta (y/d) chains. This ratio changes during ontogeny and in diseased states such as leukaemia, as well as autoimmune diseases like psoriasis.
Application Details
- Application: ELISA ; FACS ; IHC ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15°C to -25°C
- Shipping conditions: Shipping at 4°C
Documentation
Related Tools
References
- • Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746.
- • Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597.
- • Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845.
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