ANTIBODIES

Contributor Information
- Institute Netherlands Cancer Institute
Tool Details
- Tool name: Anti-CD56 [123C3]
- Alternate names: NCAM1; Neural Cell Adhesion Molecule 1
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 140 kDa
- Application: IHC ; IF ; IP
- Description: CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (ÄÂ?ÄÂĂ´) ÄÂä cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cellÄËĂÂĂÂcell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.
- Immunogen: Human small cell lung cancer membrane fraction
- Isotype: IgG1
- Research area: Cell biology; Neurobiology
- For Research Use Only
Target Details
- Target: CD56
- Target molecular weight: 140 kDa
- Target background: CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (?d) cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cellcell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.
Application Details
- Application: IHC ; IF ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
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References
- • Kibbelaar et al. 1991. Eur J Cancer. 27(4):431-5. PMID: 1851619.
- • Moolenaar et al. 1990. Cancer Res. 50(4):1102-6. PMID: 2153450.
- • Hilkens et al. 1984. Int J Cancer. 34(2):197-206. PMID: 6206003.