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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-CYP450 Aromatase [H4]
  • Alternate names: Aromatase, CYPXIX, Cytochrome P-45AROM, Cytochrome P45 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
  • Clone: H4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 55 kDa
  • Application: IHC ; IF ; WB
  • Strain: Balb/c
  • Description: CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.
  • Immunogen: Synthetic peptide corresponding to AAs 376-390 of human aromatase (KALEDDVIGYPVKK)
  • Isotype: IgG2a
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: CYP450 Aromatase
  • Target molecular weight: 55 kDa
  • Target background: CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.
  •   Local estrogen axis in the human bone microenvironment regulates estrogenreceptor-positivebreast cancer cells.
  •   Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.
  •   Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).
  •   Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.
  •   The role of anti-Mllerian hormone (AMH) during follicle development in a monovulatory species (sheep).
  •   Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.
  •   Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.
  •   Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.
  •   Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.
  •   Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.
  •   Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.
  •   Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.
  •   Cytochrome P450arom, androgen and estrogen receptors in pig sperm.
  •   Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.
  •   Cytochrome P450 aromatase expression in human seminoma.
  •   Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.
  •   Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.
  •   Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.
  •   Steroid receptor and aromatase expression in baboon endometriotic lesions.
  •   Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.
  •   Development and validation of a new monoclonal antibody to mammalian aromatase.