ANTIBODIES

Contributor Information
- Institute BioServ UK Ltd
Tool Details
- Tool name: Anti-Follistatin 288 [29/9]
- Alternate names: Follistatin, FS, FST, Active-binding protein
- Clone: [29/9]
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 37 kDa
- Application: ELISA
- Strain: Balb/c
- Description: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. 29/9 is a clone raised against recombinant Fst 288, and is used in combination, commonly as the capture, with antibody 17/2 in a two site ELISA for the detection of Follistatin.
- Immunogen: Raised to human Follistatin (Fst) 288 and recognizes both human Fst 288 and 315
- Isotype: IgG1
- Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Genetics
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: Follistation 288
- Target molecular weight: 37 kDa
- Target background: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. 29/9 is a clone raised against recombinant Fst 288, and is used in combination, commonly as the capture, with antibody 17/2 in a two site ELISA for the detection of Follistatin.
Application Details
- Application: ELISA
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • Hughes et al. 2003. Eur J Gastroenterol Hepatol. 15(2):127-31. PMID: 12560755.
- • Activin A and follistatin in acute liver failure.
- • Yuen et al. 2002. Scand J Gastroenterol. 37(2):233-8. PMID: 11843063.
- • Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis.
- • Menon et al. 2000. BJOG. 107(9):1069-74. PMID: 11002947.
- • Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma.
- • McPherson et al. 1999. Endocrinology. 140(11):5303-9. PMID: 10537161.
- • Expression of activin A and follistatin core proteins by human prostate tumor cell lines.
- • Cuckle et al. 1999. Prenat Diagn. 19(6):513-6. PMID: 10416964.
- • Maternal serum activin A and follistatin levels in pregnancies with Down syndrome.
- • Fowler et al. 1998. Hum Reprod. 13(12):3530-6. PMID: 9886545.
- • Anderson et al. 1998. Hum Reprod. 13(12):3319-25. PMID: 9886507.
- • Follistatin and activin A production by the male reproductive tract.
- • A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy.
- • Riley et al. 1998. Hum Reprod. 13(9):2624-8. PMID: 9806296.
- • Follistatin and activin A in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy.
- • Evans et al. 1998. J Endocrinol. 156(2):275-82. PMID: 9518873.
- • Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin.
- • Petraglia et al. 1997. J Clin Endocrinol Metab. 82(9):2991-5. PMID: 9284732.
- • Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases.