Product Image

Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Follistatin 288 [29/9]
  • Alternate names: Follistatin, FS, FST, Active-binding protein
  • Clone: [29/9]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 37 kDa
  • Application: ELISA
  • Strain: Balb/c
  • Description: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. 29/9 is a clone raised against recombinant Fst 288, and is used in combination, commonly as the capture, with antibody 17/2 in a two site ELISA for the detection of Follistatin.
  • Immunogen: Raised to human Follistatin (Fst) 288 and recognizes both human Fst 288 and 315
  • Isotype: IgG1
  • Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Follistation 288
  • Target molecular weight: 37 kDa
  • Target background: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. 29/9 is a clone raised against recombinant Fst 288, and is used in combination, commonly as the capture, with antibody 17/2 in a two site ELISA for the detection of Follistatin.

Application Details

  • Application: ELISA

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Hughes et al. 2003. Eur J Gastroenterol Hepatol. 15(2):127-31. PMID: 12560755.
  •   Activin A and follistatin in acute liver failure.
  •   Yuen et al. 2002. Scand J Gastroenterol. 37(2):233-8. PMID: 11843063.
  •   Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis.
  •   Menon et al. 2000. BJOG. 107(9):1069-74. PMID: 11002947.
  •   Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma.
  •   McPherson et al. 1999. Endocrinology. 140(11):5303-9. PMID: 10537161.
  •   Expression of activin A and follistatin core proteins by human prostate tumor cell lines.
  •   Cuckle et al. 1999. Prenat Diagn. 19(6):513-6. PMID: 10416964.
  •   Maternal serum activin A and follistatin levels in pregnancies with Down syndrome.
  •   Fowler et al. 1998. Hum Reprod. 13(12):3530-6. PMID: 9886545.
  •   Anderson et al. 1998. Hum Reprod. 13(12):3319-25. PMID: 9886507.
  •   Follistatin and activin A production by the male reproductive tract.
  •   A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy.
  •   Riley et al. 1998. Hum Reprod. 13(9):2624-8. PMID: 9806296.
  •   Follistatin and activin A in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy.
  •   Evans et al. 1998. J Endocrinol. 156(2):275-82. PMID: 9518873.
  •   Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin.
  •   Petraglia et al. 1997. J Clin Endocrinol Metab. 82(9):2991-5. PMID: 9284732.
  •   Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases.