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Contributor Information

  • Name Arnoud Sonnenberg
  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-Cytokeratin 18 [DEK18]
  • Alternate names: KRT18; Keratin 18
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Dog ; Human ; Feline
  • Host: Mouse
  • Molecular weight of the target: 48 kDa
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene
  • Immunogen: Cytoskeletal preperation extracted from humen epidermis
  • Isotype: IgG1
  • Research area: Cancer; Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Cytokeratin 18
  • Target molecular weight: 48 kDa
  • Target background: Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Glebov et al. 2006. Nat Cell Biol. 8(1):46-54. PMID: 16341206.
  •   Bonfrer et al. 1994. Tumour Biol. 15(4):210-22. PMID: 7524130.
  •   Vos et al. 1992. Zentralbl Veterinarmed A. 39(10):721-40. PMID: 1283472.