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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-CLEC9A [397]
  • Alternate names: C-Type Lectin Domain Family 9 Member A; HEEE9341; UNQ9341; DNGR-1; CD37; DNGR1
  • Clone: 397
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Rat
  • Application: WB
  • Description: Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells.
  • Immunogen: RBL-2H3 cells expressing mouse DNGR-1 fused to an HA epitope
  • Isotype: IgG2a
  • Research area: Immunology; Stem cell biology
  • Myeloma used: Y3.AG.1.2.3

  • For Research Use Only

Target Details

  • Target: Mouse DNGR1
  • Target background: Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Joffre et al. 2010. Eur J Immunol. 40(5):1255-65. PMID: 20333625.
  • •  Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
  • •  Sancho et al. 2009. Nature. 458(7240):899-903. PMID: 19219027.
  • •  Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
  • •  Sancho et al. 2008. J Clin Invest. 118(6):2098-110. PMID: 18497879.
  • •  Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.