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Contributor Information

  • Name Mike Price
  • Institute University of Nottingham

Tool Details

  • Tool name: Anti-Mucin 3 [1143/B7]
  • Alternate names: MUC3A; Mucin 3; Intestinal mucin-3A
  • Clone: 1143/B7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Digestive / Gastrointestinal cancer
  • Molecular weight of the target: 22 kDa
  • Application: ELISA ; IHC
  • Description: Mucin 3 (MUC3) is a glycoprotein. Distributed in colon and rectum, and to a lesser extent in breast, lung and salivary gland tissues. Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.
  • Immunogen: MUC3 tandem repeat peptide
  • Isotype: IgG2a
  • Research area: Cancer; Cell biology; Genetics

  • For Research Use Only

Target Details

  • Target: MUC3
  • Target molecular weight: 22 kDa
  • Target background: Mucin 3 (MUC3) is a glycoprotein. Distributed in colon and rectum, and to a lesser extent in breast, lung and salivary gland tissues. Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

Application Details

  • Application: ELISA ; IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Rossi et al. 2012. Histopathology. 60(7):1133-43. PMID: 22348416.
  • •  MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations.
  • •  Teshima et al. 2011. J Anat. 219(3):410-7. PMID: 21679184.
  • •  Development of human minor salivary glands: expression of mucins according to stage of morphogenesis.
  • •  Louis et al. 2006. J Cell Biochem. 99(6):1616-27. PMID: 16823775.
  • •  Selective induction of mucin-3 by hypoxia in intestinal epithelia.