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Contributor Information

  • Name Nancy Hogg
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-CD11a (Integrin aL) [38]
  • Alternate names: Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P18); LFA-1A; CD11A; Antigen CD11A (P18); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A
  • Clone: 38
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 175 kDa
  • Application: FACS ; IHC ; IF ; IP ; Fn
  • Strain: Balb/c
  • Description: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes.
  • Immunogen: Fibronectin purified monocytes.
  • Isotype: IgG2a
  • Research area: Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Integrin alpha L subunit (CD11a, LFA-1 alpha)
  • Target molecular weight: 175 kDa
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969.
  • •  Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.
  • •  Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.
  • •  Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and ?2 integrins.
  • •  Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.
  • •  Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
  • •  McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
  • •  A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
  • •  Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
  • •  The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
  • •  Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.
  • •  Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.
  • •  Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.
  • •  The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.