ANTIBODIES
Contributor Information
- Name Ayham Alnabulsi
- Institute Vertebrate Antibodies Limited
Tool Details
- Tool name: Anti-IgNAR [V39]
- Alternate names: Small-spotted catshark IgNAR, IgNAR antibody, Nanobody, Single domain antibody
- Clone: V39
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Small-spotted catshark
- Host: Mouse
- Application: ELISA ; WB
- Strain: Balb/c
- Description: Sharks, and other members in Chondrichthyes, produce, apart from the expected IgM and IgW, a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR antibody is composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain. The distinct structure of IgNAR domains leads to extremely high stability. In addition, VNAR is around 10 times smaller than standard antibodies and able to continue to function and exist within very extreme conditions. These properties allow IgNAR to penetrate tissues easier in vivo to improve bioavailability for pharmaceutical applications. Anti-IgNAR antibody (V39) can be used to monitor IgNAR levels in shark following immunization
- Immunogen: Ovalbumin-conjugated short synthetic peptide
- Isotype: IgG1 kappa
- Myeloma used: P3X63Ag8.653
- For Research Use Only
Target Details
- Target: IgNAR immunoglobulin heavy chain membrane and secretory forms
- Target background: Sharks, and other members in Chondrichthyes, produce, apart from the expected IgM and IgW, a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR antibody is composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain. The distinct structure of IgNAR domains leads to extremely high stability. In addition, VNAR is around 10 times smaller than standard antibodies and able to continue to function and exist within very extreme conditions. These properties allow IgNAR to penetrate tissues easier in vivo to improve bioavailability for pharmaceutical applications. Anti-IgNAR antibody (V39) can be used to monitor IgNAR levels in shark following immunization
Application Details
- Application: ELISA ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
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