ANTIBODIES
Contributor Information
- Name Gerard Evan
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-cMyc [PM3E7]
- Clone: PM3E7
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Cancer type: Gynaecologic cancer; Digestive / Gastrointestinal cancer; Breast cancer; Lung
- Application: IHC ; IP ; WB
- Strain: Balb/c
- Description: The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.
- Immunogen: A synthetic peptide APSEDIWKKFEL corresponding to amino acids 44-55 of c-Myc coupled to PPD
- Isotype: IgG2a
- Research area: Cancer; Cell biology; Genetics; Stem cell biology
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: cMyc, c-Myc
- Target background: The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.
Application Details
- Application: IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Evan et al. 1988. Curr Top Microbiol Immunol. 141:189-201. PMID: 3063442.
- • Immunological probes in the analysis of myc protein expression.
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