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Contributor Information

  • Name Margaret Goodall
  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-CD21 [BU79]
  • Alternate names: Complement receptor type 2; CR2; complement C3d receptor, C3DR, Epstein-Barr virus receptor
  • Clone: BU80
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC
  • Strain: Balb/c
  • Description: Cluster of differentiation 21 (CD21) is a protein encoded by the CR2 gene in humans. It is involved in the complement system and binds to iC3b (an inactive derivative of C3b). B cells are known to have CR2 receptors on their surfaces allowing the complement system to act in B-cell maturation and activation. Genetic variations are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) which is a chronic autoimmune disease with an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes.
  • Immunogen: Daudi cell line (B lymphoblast)
  • Isotype: IgG1
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: CD21
  • Target background: Cluster of differentiation 21 (CD21) is a protein encoded by the CR2 gene in humans. It is involved in the complement system and binds to iC3b (an inactive derivative of C3b). B cells are known to have CR2 receptors on their surfaces allowing the complement system to act in B-cell maturation and activation. Genetic variations are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) which is a chronic autoimmune disease with an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes.

Application Details

  • Application: IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Leucocyte Typing VI, (1998): edited by T. Kishimoto, Garland Publishing, New York.
  • •  Ling et al. 1998. Clin Exp Immunol. 113(3):360-6. PMID: 9737663.
  • •  Ling et al. 1998. Clin Exp Immunol. 113(3):360-6. PMID: 9737663.
  • •  Buescher et al. 1991. Public Health Rep. 106(3):333-8. PMID: 1905057.