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Contributor Information

  • Name Martin Humphries
  • Institute University of Manchester

Tool Details

  • Tool name: Anti-CD49e [SNAKA51]
  • Alternate names: Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A
  • Clone: SNAKA51
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; Fn ; WB
  • Description: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
  • Immunogen: Whole cells corresponding to human Integrin alpha5.
  • Isotype: IgG2a kappa
  • Research area: Cell biology; Apoptosis and autophagy; Cell signaling and signal transduction; Immunology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Integrin alpha5 (CD49e)
  • Target background: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Application Details

  • Application: IF ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.
  • •  Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
  • •  Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
  • •  A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.