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Contributor Information

  • Name Joy Burchell ; Joyce Taylor-Papadimitriou
  • Institute Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-MUC1 [HMFG2]
  • Alternate names: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
  • Clone: rHMFG2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Breast cancer; Gynaecologic cancer; Digestive / Gastrointestinal cancer;
  • Application: ELISA ; FACS ; IHC ; IP ; WB
  • Description: Recombinant antibody which detects several glycoforms of MUC1, a marker of breast cancer. Background and Research Application Mucin-1 (MUC1) is a membrane protein present on normal human breast epithelial cells and cell lines derived from breast carcinomas. Human MUC1 is also localised on the surface of the human milk fat globule. MUC1 is a differentiation marker and specific breast epithelial marker in normal and neoplastic mammary development and can be used to monitor response to breast cancer treatment and disease recurrence. Lower levels over time may be indicative of a positive response to treatment. It is upregulated in the lactating breast and in carcinomas. MUC1 also is involved in tumour progression and transcription through regulation of p53. This is a recombinant version of the anti-MUC1 antibody. Anti-MUC1 can react with unglycosylated MUC1, and several glycoforms.
  • Immunogen: Milk fat globule followed epithelial cells cultured from milk
  • Immunogen UniProt ID: P15941
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: Mucin1 (MUC1)
  • Target background: Recombinant antibody which detects several glycoforms of MUC1, a marker of breast cancer. Background and Research Application Mucin-1 (MUC1) is a membrane protein present on normal human breast epithelial cells and cell lines derived from breast carcinomas. Human MUC1 is also localised on the surface of the human milk fat globule. MUC1 is a differentiation marker and specific breast epithelial marker in normal and neoplastic mammary development and can be used to monitor response to breast cancer treatment and disease recurrence. Lower levels over time may be indicative of a positive response to treatment. It is upregulated in the lactating breast and in carcinomas. MUC1 also is involved in tumour progression and transcription through regulation of p53. This is a recombinant version of the anti-MUC1 antibody. Anti-MUC1 can react with unglycosylated MUC1, and several glycoforms.

Application Details

  • Application: ELISA ; FACS ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Original hybridoma first published in: Taylor-Papadimitriou et al. 1981. Int J Cancer. 28(1):17-21. PMID: 7309278.
  • •  Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.