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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-FANCB [M38P3E10]
  • Alternate names: FA2, FAAP9, FAAP95, FAB, FACB, Fancb, FANCB_HUMAN, Fanconi anemia associated polypeptide of 95 kDa, Fanconi anemia group B protein, Fanconi anemia, complementation group B, Fanconi anemia-associated polypeptide of 95 kDa, Protein FACB
  • Clone: M38P3E10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 98 kDa
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
  • Immunogen: Ovalbumin-conjugated synthetic peptide- DRRENIHPYR
  • Isotype: IgG1 kappa
  • Research area: Cancer; Genetics
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Fanconi Anemia, Complementation Group B (FANCB)
  • Target molecular weight: 98 kDa
  • Target background: FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation