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Anti-SCL [1C10]

Cat. #152649

Tool name: Anti-SCL [1C10]
Clone: 1C10
Tool type: Antibodies
Tool sub-type: Primary antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Zebrafish
Host: Mouse
Application: IF ; WB
Description: Zebrafish has an immune system similar to human and mutant zebrafish generate models for human disease. "Stem Cell Leukemia" (SCL) was assigned to a gene involved in a t(1;14) translocation associated with an acute leukemia with early T-cell phenotype and myeloid differentiation potential. SCL is a transcription factor of the basic helix-loophelix (bHLH) family and normally functions as a critical regulator of hematopoiesis. It is expressed in hematopoietic stem cells (HSCs), erythroid and megakaryocytic lineages but not in granulocyte/monocytes or lymphocytes. It is also expressed in the endothelium. SCL could be a major factor for the determination of hematopoietic and endothelial cell lineages. The study of SCL gene in zebrafish improves the understanding of genetic mechanisms involved in stem cell development and leukaemia generation. Most importantly, the key molecules involved in leukaemia could be identified and targeted by therapeutic drugs.
Immunogen: GST-SCL (C-terminal) fusion protein
Isotype: IgG1
Research area: Stem cell biology
Myeloma used: Sp2/0-Ag14

Target: Stem Cell Leukemia protein
Target background: Zebrafish has an immune system similar to human and mutant zebrafish generate models for human disease. "Stem Cell Leukemia" (SCL) was assigned to a gene involved in a t(1;14) translocation associated with an acute leukemia with early T-cell phenotype and myeloid differentiation potential. SCL is a transcription factor of the basic helix-loophelix (bHLH) family and normally functions as a critical regulator of hematopoiesis. It is expressed in hematopoietic stem cells (HSCs), erythroid and megakaryocytic lineages but not in granulocyte/monocytes or lymphocytes. It is also expressed in the endothelium. SCL could be a major factor for the determination of hematopoietic and endothelial cell lineages. The study of SCL gene in zebrafish improves the understanding of genetic mechanisms involved in stem cell development and leukaemia generation. Most importantly, the key molecules involved in leukaemia could be identified and targeted by therapeutic drugs.

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