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Contributor Information

  • Name Peter Beverley
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Alkaline phosphatase [AP1B9]
  • Clone: AP1B9
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human
  • Host: Mouse
  • Application: IHC
  • Strain: Balb/c
  • Description: Monoclonal antibody which can aid detection of ovarian and testicular cancers.
  • Immunogen: Calf Alkaline phosphatase
  • Immunogen UniProt ID: P09923
  • Isotype: IgG1
  • Research area: Cancer; Cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Calf alkaline phosphatase
  • Target background: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.

Application Details

  • Application: IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hoene et al. 2020. J Biomed Mater Res A. 108(4):871-881. PMID: 31846170.
  • •  Lucke et al. 2018. J Biomed Mater Res A. 106(10):2726-2734. PMID: 30051967.
  • •  Lucke et al. 2015. Biomed Res Int. 2015:938059. PMID: 25648958.
  • •  Erlach et al. 2002. J Virol. 76(6):2857-70. PMID: 11861853.
  • •  Tumor control in a model of bone marrow transplantation and acute liver-infiltrating B-cell lymphoma: an unpredicted novel function of cytomegalovirus.