Product Image

Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-BLK [BLK154/D4]
  • Clone: BLK154/D4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: WB
  • Description: B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.
  • Immunogen: Recombinant protein corresponding to amino acids 53- 224 of human BLK
  • Isotype: IgG1
  • Research area: Apoptosis and autophagy
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: BLK
  • Target background: B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-Collagen Type VII [LH7.2]

#152691
Product Image

Anti-TK15 epitope tag [TK 15] mAb

#151272
Product Image

Anti-Cytochrome P450 2R1 [M26-P6H1]

#152121

References

  • •  Borowiec et al. 2009. Proc Natl Acad Sci U S A. 106(34):14460-5. PMID: 19667185.
  • •  Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.
  • •  Wasserman et al. 1995. J Immunol. 155(2):644-51. PMID: 7608542.
  • •  Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.
  • •  Islam et al. 1995. J Immunol. 154(3):1265-72. PMID: 7822795.
  • •  Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
  • •  Yao et al. 1993. Proc Natl Acad Sci U S A. 90(17):7946-50. PMID: 7690139.
  • •  Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.