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Contributor Information

  • Name Tatjana Crnogorac-Jurcevic
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-SPAG1 [10G1/2]
  • Clone: 10G1/2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 104 kDa
  • Application: IF ; IP ; WB
  • Description: Sperm-associated antigen 1 (SPAG1) has been shown to be expressed in high levels in pancreatic adenocarcinoma. SPAG1 is found in high levels in testis and a large proportion of pancreatic ductal adenocarcinomas (PDAC). It has been seen that in PDAC's SPAG1 expression is predominantly cytoplasmic and confined to malignant cells. The extent and intensity of SPAG1 expression has been shown to be associated with stage and tumour nodal status and this has led to the suggestion that SPAG1 is a novel marker of PDAC progression.
  • Immunogen: Synthetic peptide SPA-3 (sequence designed to avoid TPR motifs - KTAPFNKEKERRKIEIQEVNE)
  • Isotype: IgG
  • Research area: Cancer; Developmental biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: SPAG1
  • Target molecular weight: 104 kDa
  • Target background: Sperm-associated antigen 1 (SPAG1) has been shown to be expressed in high levels in pancreatic adenocarcinoma. SPAG1 is found in high levels in testis and a large proportion of pancreatic ductal adenocarcinomas (PDAC). It has been seen that in PDAC's SPAG1 expression is predominantly cytoplasmic and confined to malignant cells. The extent and intensity of SPAG1 expression has been shown to be associated with stage and tumour nodal status and this has led to the suggestion that SPAG1 is a novel marker of PDAC progression.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Neesse et al. 2007. Oncogene. 26:1533-45. [PMID: 16983343]